Keith Smith, M. Barratt
Jan 10, 2007
Citations
0
Influential Citations
39
Citations
Journal
The Journal of organic chemistry
Abstract
Lithiation of 3-methylthiophene with lithium 2,2,6,6-tetra-methylpiperidide (LiTMP) is highly selective at the 5-position, and reaction with a range of electrophiles gives high yields of the corresponding 2,4-disubstituted thiophenes, even when unhindered electrophiles are used.