G. Kumar, M. Zeller, R. Gonnade
Jul 23, 2014
Citations
0
Influential Citations
11
Citations
Journal
Tetrahedron Letters
Abstract
A new class of hydrazinylquinoline regio-isomers has been synthesized through SNAr reaction of 2,4dichloroquinolines with hydrazine hydrate. The reaction stops at the mono-substitution product with high regioselectivity at the C4 rather than C2 position of dichloroquinolines. The hydrazinylquinolines were subsequently converted into aminoquinoline substituted pyrrolidin-2,5-diones in the presence of Eaton’s reagent.