Ingvild T. Lund, P. Bøckmann, E. Jacobsen
Nov 17, 2016
Citations
0
Influential Citations
23
Citations
Journal
Tetrahedron
Abstract
Abstract Both enantiomers of 4 -( 3 -chloro- 2 -hydroxypropoxy)phenyl)acetamide has been synthesized in 98.5–99% enantiomeric excess by use of lipase B from Candida antarctica as catalyst. The R -alcohol is a building block for the cardioselective β-blocker ( S )-atenolol ((S)- 2 -( 4 -( 2 -hydroxy- 3 -(isopropylamino)propoxy)phenyl)acetamide . Performing kinetic resolutions of 3-chloro-1-phenoxy-2-propanol and 3-bromo-1-phenoxy-2-propanol with vinyl butanoate as acyl donor and the same CALB enzyme, but a different preparation, showed higher E -values than previously reported.