Longqiang Jiang, Tao Gao, Zhi Li
Feb 10, 2016
Citations
0
Influential Citations
15
Citations
Journal
Tetrahedron Letters
Abstract
1,2-Oxazol derivatives 3 were prepared by a highly regioselective 1,3-dipolar cycloaddition of nitrile oxides and α,β-acetylenicaldehydes 1 in good yields. Reactive nitrile oxides were generated in situ from stable chloro-oxime reagents 2 and triethyl amine. The cycloaddition reaction showed broad substrate scope and good functional group compatibility.