A. Alizadeh, Vahideh Sadeghi, Fahimeh Bayat
Oct 7, 2014
Citations
0
Influential Citations
4
Citations
Journal
Synlett
Abstract
A one-pot, diastereoselective synthesis of diverse azabicyclo[2.2.2]octanes from readily available starting materials is reported. The key strategy relies on creation of 2-aminoprop-1-ene-1,1,3-tricarbonitrile through dimerization of malononitrile which undergoes nucleophilic attack on dibenzalacetone at three sites leading to bicyclo[2.2.2]octanes.