R. Kumar, Y. Joshi
May 12, 2009
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Journal
ChemInform
Abstract
Sulphonation of 5-(2-ethoxyphenyl)-1-methyl-3-propyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one (1) with chlorosulphonic acid affords 5-[(5-chlorosulphonyl-2-ethoxy)pyrimidin]-1 -methyl-3-propyl-1,6-dihydro-7H-pyrazolo[4,3-d]-pyrimidin-7-one (2). Compound (2) condensed with different β -diketones/β -ketoesters (3a-e) to obtain new β-diketones/ β-ketoesters (4a-e). These β -diketones/β -ketoesters were condensed with o-phenylenediamine (o-PDA) in presence of lanthanum(III) nitrate hexahydrate to afford biologically active 3H-1,5-benzodiazepines (5a-e) in excellent yield. The compounds (5a-e) have been screened for antimicrobial, antifungal and anthelmintic activities.