N. Rivera, Y. Hsiao, Jennifer A. Cowen
Jan 1, 2001
Citations
0
Influential Citations
9
Citations
Journal
Synthetic Communications
Abstract
2-Amino-3-pyridinecarboxaldehyde is synthesized in a highly efficient process via ortho-lithiation of 2-(pivaloylamino)pyridine and reaction with DMF, followed by acid hydrolysis. Major impurities were identified and were cleanly eliminated through careful choice of base and solvent.