G. Wanyoike, O. Onomura, T. Maki
Apr 30, 2002
Citations
0
Influential Citations
45
Citations
Journal
Organic letters
Abstract
[reaction: see text] Electrochemical oxidation of N-acylated serine derivative 1b in methanol gave optically active methoxylated compound 2b with an enantiomeric excess of up to 80%. The bulky o-phenyl benzoyl N-protecting group was found to be the main contributing factor for the enhanced enantioselectivity. The mechanistic aspect of this methoxylation reaction was investigated and found to proceed via a retention mechanism.