Qiao‐Qiao Min, Z. Yin, Zhange Feng
Jan 14, 2014
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Influential Citations
136
Citations
Quality indicators
Journal
Journal of the American Chemical Society
Abstract
A first example of Pd-catalyzed gem-difluoroallylation of organoborons using 3-bromo-3,3-difluoropropene (BDFP) in high efficiency with high α/γ-substitution regioselectivity has been developed. The reaction can also be extended to substituted BDFPs and has advantages of low catalyst loading (0.8 to 0.01 mol %), broad substrate scope, and excellent functional group compatibility, thus providing a facile route for practical application in drug discovery and development.