You-Qing Wang, Yuanyuan Ren
2015
Citations
0
Influential Citations
11
Citations
Journal
Chinese Journal of Catalysis
Abstract
Abstract Various substituted dibenzo[ b,f ][ 1,4 ]oxazepines as seven-membered cyclic imines underwent a highly enantioselective direct Mannich reaction with acetone when catalyzed by proline. These reactions gave a range of optically active β-carbonyl seven-membered N -heterocycles with excellent enantioselectivity (93%–98% ee). With 2-butanone as a Mannich donor, the single regioselective product was obtained with 96%–97% ee. The absolute configuration of the product was assigned to be R by X-ray single crystal analysis of its derivative.