Xiao-qing Li, Lan-zhi Wang
Feb 1, 2014
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0
Influential Citations
11
Citations
Journal
Chinese Chemical Letters
Abstract
Abstract A general, mild and efficient protocol for the synthesis of ethyl 4-methyl-2-(thiophen)-2,5-dihydro-1,5-benzodiazepine-3-carboxylate is achieved for first time using H 3 PMo 12 O 40 in ethanol at 0 °C by a one-pot, three-component condensation of various thiophene aldehydes, substituted o -phenylenediamines and ethyl acetoacetate. Compared with the conventional synthesis method, this procedure has the advantages of convenient operation, excellent yields, and environmentally benign. A plausible formation mechanism has been proposed. The structure of the products is characterized by 1 H NMR, IR, MS and elemental analysis.