Zhi‐Liang Shen, Zhihua Peng, Chun-Ming Yang
Jan 30, 2014
Citations
0
Influential Citations
13
Citations
Journal
Organic letters
Abstract
Chloro-substituted triethylsilyl enol ethers derived from cyclohexanone and related ketones are converted with aluminum powder in the presence of indium trichloride to functionalized allylic aluminum reagents which represent a new type of synthetic equivalent of metal enolates. These allylic organometallics undergo highly diastereoselective additions to aldehydes and methyl aryl ketones, giving aldol products with a β-quaternary center.