George T. Lee, Xinglong Jiang, T. R. Vedananda
Oct 1, 2004
Citations
0
Influential Citations
5
Citations
Journal
Advanced Synthesis & Catalysis
Abstract
A facile highly regioselective process is described for the formation of 4-chloromethyl-1,3-oxazoles from 1,3-oxazole N-oxide/HCl salts. An explanation is presented for the high regioselectivity in deoxygenation-chlorination using POCl3 with HCl salts compared to the corresponding free N-oxides. The method is quite general and the products are isolated by direct precipitation in all cases studied.