Shin Aoki and, E. Kimura
May 2, 2000
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0
Influential Citations
101
Citations
Quality indicators
Journal
Journal of the American Chemical Society
Abstract
Highly selective and efficient recognition of thymidine and uridine nucleotides such as 3‘-dTMP (thymidine 3‘-monophosphate), 5‘-dTMP (thymidine 5‘-monophosphate), 2‘-UMP (uridine 2‘-monophosphate), 3‘-UMP (uridine 3‘-monophosphate), 5‘-UMP (uridine 5‘-monophosphate), 5‘-dTDP (thymidine 5‘-diphosphate), 5‘-dTTP (thymidine 5‘-triphosphate), AZTMP (3‘-azido-3‘-deoxythymidine 5‘-monophosphate), and AZTDP (3‘-azido-3‘-deoxythymidine 5‘-diphosphate) with ditopic dimeric zinc(II) complexes of macrocyclic 12-membered tetramines, meta- and para-xylyl-bis(Zn2+-cyclen)s (Zn2L4 and Zn2L5) (cyclen = 1,4,7,10-tetraazacyclododecane) has been studied by potentiometric pH titration, isothermal titration calorimetry, UV spectrophotometric titration, and NMR titration. The apparent 1:1 complexation constants for 5‘-dTMP, Kapp (= [(Zn2L)−(S-−OPO32-)]/[Zn2L]free[S−OPO32-]free (M-1)), where S- denotes the imide-deprotonated thymine part), with Zn2L4 or Zn2L5 determined by potentiometric pH titration showed a more stable compl...