R. Anilkumar, D. Burton
Aug 25, 2003
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Influential Citations
19
Citations
Journal
Tetrahedron Letters
Abstract
Abstract Various 1-aryl-1,2,2,2-tetrafluoroethanes (ArCHFCF 3 , Ar=phenyl, substituted phenyl, naphthyl, heteroaryl) were synthesized by the fluorination of the corresponding alcohols with DAST. Dehydrofluorination of ArCHFCF 3 using lithium hexamethyldisilazide (LHMDS) base in THF at room temperature produced 1,2,2-trifluorostyrenes (ArCF=CF 2 ) in 61–91% isolated yields. This procedure provides an excellent non-organometallic alternative to the generally used metallation-Pd(0) coupling methods.