A. Kanazawa, Jean-Noël Denis, A. Greene
Mar 1, 1994
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0
Influential Citations
129
Citations
Quality indicators
Journal
Journal of Organic Chemistry
Abstract
A high-yield synthesis of the p-methoxybenzylidene-protected docetaxel (Taxotere) side chain, a useful derivative for efficient, epimerization-free esterification of the 7,10-bis[(trichloroethoxy)carbonyl] derivative of 10-desacetylbaccatin III for the preparation of docetaxel, has been effected; the C-4 and C-5 stereocentes of the 1,3-oxazolidine are generated with complete (≥99%) stereocontrol whereas that at C-2 is produced with 96% selectivity