D. Chekmarev, S. V. Shorshnev, A. E. Stepanov
Oct 16, 2006
Citations
0
Influential Citations
14
Citations
Journal
Tetrahedron
Abstract
A highly efficient synthesis of the potent CDKs (cyclin-dependent kinases) inhibitors, aloisines (substituted 5H-pyrrolo[2,3-b]pyrazines) is presented. The method is based on highly selective monosubstitution of a single chlorine atom in 2,3-dichloropyrazine with lithiated ketones, esters, and nitriles followed by co-cyclization of the resulting intermediates with primary amines or hydrazines.