Javier González‐Sabín, F. Morís-Varas, C. Peña
Jul 1, 2009
Citations
0
Influential Citations
6
Citations
Journal
Journal of Molecular Catalysis B-enzymatic
Abstract
Abstract A novel and efficient chemoenzymatic protocol for the preparation of both enantiomers of trans -2-aminocyclopentanol is described. The key steps of this strategy are the synthesis and subsequent Burkholderia cepacia lipase-catalyzed resolution of the racemic precursor trans -2-(diallylamino)cyclopentanol. In addition, a variety of diversely substituted derivatives are prepared from the enantiopure compounds isolated in the biotransformation by means of simple protection–deprotection reactions.