A. Siskos, A. Hill
Jan 20, 2003
Citations
0
Influential Citations
6
Citations
Journal
Tetrahedron Letters
Abstract
Abstract Labeled glycerol is a widely used biochemical probe to investigate biosynthetic pathways. A highly efficient synthesis of [1- 13 C, 18 O]- and [1- 13 C, 2 H 2 ]-glycerol is described in which the 13 C label is introduced using cyanide. The 18 O label was introduced by a Pinner synthesis and reduction of the ester 5 allowed incorporation of the 2 H labels.