N. Kuhnert, T. N. Danks
2001
Citations
0
Influential Citations
26
Citations
Journal
Green Chemistry
Abstract
A number of 1,3-oxazolidines, derived from enantiomerically pure amino alcohols such as (−)-ephedrine and (+)-pseudoephedrine, have been synthesised under solvent-free conditions using a focused microwave reactor. The condensation reaction between the amino alcohol and an aldehyde yields 1,3-oxazolidines in excellent yields and diastereoselectivities. Prolonged microwave irradiation increases the diastereoselectivity of the reaction and produces the thermodynamically more stable diastereomer.