S. Jew, Byeong-Seon Jeong, Jeong-hee Lee
May 2, 2003
Citations
0
Influential Citations
49
Citations
Journal
The Journal of organic chemistry
Abstract
Systematic investigations to develop an efficient enantioselective synthetic method for alpha-alkyl-alanine by catalytic phase-transfer alkylation were performed. The alkylation of 2-naphthyl aldimine tert-butyl ester, 1E, with RbOH and O(9)-allyl-N-2',3',4'-trifluorobenzylhydrocinchonidinium bromide, 6, at -35 degrees C showed the highest enantioselectivities, up to 96% ee.