Giorgio Della Sala, A. Lattanzi
Jul 8, 2009
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0
Influential Citations
59
Citations
Journal
Organic letters
Abstract
The desymmetrization of N-acylaziridines with Me(3)SiSPh, catalyzed by commercially available (R) and (S)-VAPOL hydrogen phosphate, produced beta-(N-acylamino)phenylthioethers in a highly enantioselective and efficient manner (78-99% ee). The selection of the suitable aziridine/nucleophile/catalyst molar ratio is crucial to obtain high ee's.