K. Makino, T. Goto, J. Ohtaka
2009
Citations
0
Influential Citations
8
Citations
Journal
Heterocycles
Abstract
(2R,3R)-2-Amino-3-cyclohexyl-3-hydroxypropionic acid, a β-hydroxy-α-amino acid in a new CCR5 antagonist, was efficiently synthesized by the Noyori asymmetric hydrogenation of a-benzoylamino-β-keto ester (6) and intramolecular S N 2-type inversion as the key steps.