A. Mangia, S. Silingardi, F. Bortesi
May 1, 1979
Citations
0
Influential Citations
2
Citations
Journal
Journal of pharmaceutical sciences
Abstract
A rapid and accurate quantitative determination of cephacetrile in finished bulk and dosage forms is reported. The high-performance liquid chromatographic method is free of interference by acetyl hydrolysis products and synthesis by-products. The assay can be performed in about 15 min, affording less than 0.7% coefficients of variation within and between days. The chromatographic results are in good agreement with the microbiological assay requested by the "Code of Federal Regulations" for certification of cephacetrile sodium.