Jer-Yann Lin, Mei-hui Yang
Aug 6, 1993
Citations
1
Influential Citations
22
Citations
Journal
Journal of Chromatography A
Abstract
Abstract The synthesis and chiral recognition ability of a series of four chiral stationary phases (CSPs) containing 2,4-bis [carbamoyl(alkyl)methylamino]-6-chloro- s -triazine (designated phase A) are described. The synthesis of these CSPs is achieved through amide formation by bonding 2,4-bis[carboxy(alkyl)methylamino]-6-chloro- s -triazine onto 3- aminopropyl silica gel. Such phases are quite effective for high-performance liquid chromatographic separation of a racemic mixture of five typical amino acids. The chromatographic behaviour of these CSPs was studied. Comparison of these CSPs with the s -triazine-derived CSP (designated phase B), which bears a tripeptide chiral moiety, is also discussed. The present study clearly indicates that an s -triazine-terminated CSP derived from certain l - amino acids (phase A), instead of tripeptide, is effective enough for the separation of enantiomeric amino acids.