Andrew J. Carpenter, Derek J. Chadwick
1985
Citations
0
Influential Citations
40
Citations
Journal
Tetrahedron Letters
Abstract
Abstract The course of lithiation of furan- and thiophene-2-carboxylic acids is critically dependent on the identity of the lithium base allowing high-yielding syntheses of 2,3- and 2,5-disubstituted thiophenes: the proposed use of a trimethylsilyl blocking group to control metallation in the furan acid provides a useful route to 2,3-disubstituted furans.