A. Adib, P. Potier, S. Doronina
Apr 28, 1997
Citations
1
Influential Citations
26
Citations
Journal
ChemInform
Abstract
Abstract An improved synthesis of the deoxy-2-fluoroinosine nucleoside is described, that makes use of mild fluorination (polyvinylpyridinium polyhydrogenfluoride) and O-silyl deprotection (triethylamine trihydrofluoride) reactions. The derived 5′-dimethoxytrityl-2-fluoroinosine-3′-phosphoramidite was incorporated into 10-, 15- and 20- mer oligonucleotides containing up to 7 non-natural bases. © 1997 Published by Elsevier Science Ltd.