Christopher M. Mapes and, N. Mani
Apr 19, 2007
Citations
0
Influential Citations
4
Citations
Journal
Organic Process Research & Development
Abstract
We report a procedure for the concise and high-yielding syntheses of 1-piperidin-4-yl-substituted butyro- and valerolactams. Beginning with 1-benzyl-4-piperidone and γ- or δ-amino esters or acids, we have effected a tandem reductive amination−lactamization using sodium triacetoxyborohydride. This procedure represents an inexpensive and scaleable alternative to previous multistep syntheses of these important pharmaceutical building blocks.