J. Liu, J. Cheng
Mar 1, 1997
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Influential Citations
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Quality indicators
Journal
Zhongguo yao li xue bao = Acta pharmacologica Sinica
Abstract
AIM To study the effect of 6,7-dinitroquinoxaline-2,3-dione (DNQX) and bicuculline (Bic) on benzyl-penicillin-induced-epilepsy (PIE) and electroacupuncture (EA) antiepilepsy in rats. METHODS Epilepsy was elicited by intra-hippocampal microinjection of benzylpenicillin in rats. The analysis of electroencephalogram (EEG) and power spectrum was used to measure the extent of convulsion. RESULTS EA or DNQX (1 microgram) showed partial inhibitory effect on PIE. EA + DNQX caused further inhibition of PIE, and Bic attenuated EA antiepileptic effect. CONCLUSION Antagonization of GABA-A receptor attenuated EA antiepileptic effect, and EA acted synergistically with the antagonists of non-N-methyl-D-aspartate (non-NMDA) receptors.