S. Feinberg
1946
Citations
0
Influential Citations
17
Citations
Journal
The Journal of allergy
Abstract
Abstract 1.1. In recent years, increased effort has been expended in the attempt to produce drugs which are antihistaminic, antianaphylactic, and antiallergic. While the first substances had a low index of efficiency and high degree of toxicity, more recent compounds have shown greater possibilities. 2.2. Fourneau and his followers, after trial of numerous synthetic substances, have finally settled on N-phenyl-N′benzyl-N-dimethylethylenediamine (2339 RP) as the most useful. This drug was claimed to be highly effective in allergic manifestations. In this country, the recent ventures in this field have consisted of experimentation, particularly with two compounds, β-dimethylaminoethyl benzhydryl ether (A-524) and pyridil-N′benzyl-N-dimethylethylenediamine (63). 3.3. Both of these drugs apparently have definite effect on some of the manifestations of allergy, such as urticaria and angioneurotic edema in a considerable percentage, and possibly on some other manifestations and pruritus. 4.4. Even at this early stage of experimentation it is evident that the use of these drugs will be limited because they will not be effective in many of the manifestations of allergy and because of the toxicity and undesirable reactions. Further limitation of their effectiveness is, of course, evident from the fact that, at best, such remedies are only palliative and that they do not produce any lasting benefit. 5.5. It is hoped that the advent of this type of therapy will not becloud the issue nor dampen the ardor of our search for information of more basic value that will help us to understand the mechanism of the allergic reaction and the constitutional background of allergy, and find a means for the correction of both.