T. White
Feb 1, 1966
Citations
0
Influential Citations
46
Citations
Journal
British journal of pharmacology and chemotherapy
Abstract
In his pioneer work on histamine metabolism in mammals Schayer (1959) demonstrated two main pathways for histamine catabolism. One of these leads to the formation of 1,4-methylhistamine [1-methyl-4-(P-aminoethyl)imidazole, hereafter referred to as methylhistamine] and depends on the enzyme histamine N-methyl transferase. This enzyme is present in particularly large amounts in brain tissue (Brown, Tomchick & Axelrod, 1959; Axlerod, McLean, Albers & Weissbach, 1961). More recently the occurrence of methylhistamine in brain tissue has been reported (Fram & Green, 1963; Perry, Hansen, Foulks & Ling, 1965). This paper presents a method for the determination of methylhistamine in tissues, and observations on the distribution in cat brain of histamine and methylhistamine under normal conditions and under the influence of drugs.