Vargas-González Brigido Alan, Castro-Pastrana Lucila Isabel, Mendoza María Eugenia
Jul 1, 2016
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Influential Citations
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Journal
Journal of Nanomedicine Research
Abstract
Sodium meclofenamate is a widely used anti-inflammatory drug which has to be administered periodically to keep their physiologically active dose in serum. The development of nanostructured drug delivery systems may be useful for sustained release of the molecule for longer time periods. Magnetic hollow iron oxide nanocapsules were successfully synthesized by the solvothermal decomposition of an urea/FeCl3?6H2O complex, as metal precursor, and Ethylene Glycol (EG) as solvent; the reaction was carried out at 200°C. The morphology and physical properties of the nanocapsules were characterized using X-Ray Diffraction (XRD), Transmission Electron Microscopy (TEM), Scanning Electron Microscopy (SEM), Infrared Spectroscopy (IR), and Energy Dispersive X-Ray Spectroscopy (EDS). UV-Vis was used to determine the adsorption and release capacity of Sodium Meclofenamate (SMF). Spherical Hollow Magnetic Nanocapsules (HMNCs) 220-230 nm in size were obtained; they were able to load up to 18% of total available SMF in solution after 18 hours and then release efficiently and steadily 45% of it after 6 hours in aqueous suspensions.