Amit Kumar, Stephanos Ghilagaber, Jamie D. Knight
Sep 23, 2002
Citations
0
Influential Citations
6
Citations
Journal
Tetrahedron Letters
Abstract
Abstract ( S )-3-Amino-4-[(1 H )imidazol-4-yl]butanoic acid ( 1 ), a β-amino acid which is a homologue of l -histidine, has been synthesised in five steps from l -histidine methyl ester. The presence of N (α)- and N (Im)-2,4,6-trimethylbenzenesulfonyl protecting groups was crucial to the success of the route, the key step of which involved the ring opening of an aziridine intermediate by sodium cyanide.