S. Palacios, M. Lilue
2017
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Abstract
Tibolone is a progestin structurally related to norethynodrel. Its mechanism of action is tissue specific. Tibolone, after oral ingestion, is converted to three active metabolites which have different binding affinities to the various sexual steroid receptors. Tibolone has been used in the treatment of climacteric symptoms, improving mood and sexual response, and in the prevention and treatment of osteoporosis. It increases the risk of stroke and its behavior in the breast is similar to estrogen plus progestin menopause therapy.