Yi Shi, J. Dabrowiak
Dec 1, 2012
Citations
0
Influential Citations
11
Citations
Journal
Inorganica Chimica Acta
Abstract
A Pt(IV) complex, 1-adamantanemethylamine–Pt(IV), 2, a potential prodrug of the Pt(II) anticancer agent cisplatin was synthesized by tethering 1-adamantanemethylamine to oxoplatin using a dicarboxylate linker. The host–guest inclusion complex of 2 with β-cyclodextrin, is less toxic toward neuroblastoma SK-N-SH cells than cisplatin. Reduction of the inclusion complex with ascorbic acid produces a Pt(II) product that binds to and unwinds pBR322 form I DNA in a manner that is similar to that of cisplatin.