Zhu Kai
2007
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Journal
Chinese Journal of Pharmaceutical Analysis
Abstract
Objective: To establish a method of HPLC for determination the content and uniformity of clorprenaline hydrochloride tablets. Methods:A Shim - pack C_(18) (4.6 mm × 150 mm,5μm) column was used. MeOH - phosphate buffer solution (pH 7.0 ) (6:4) was used as the mobile phase. The flow rate was 1.0 mL · min~(-1). The detection wavelength was 213 nm. Results: There was a good linear within the range of 21 - 420 μg · mL~(-1) ( r =0. 9999). The average recovery was 100. 2% , RSD = 1.3% (n = 9 ). Conclusion:The method is simple, reliable, accurate and can be applied to the quality control of the preparation.