Luo Chuan-huan
2005
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Journal
Chinese Journal of Pharmaceutical Analysis
Abstract
Objective: To establish HPLC method for determination of content of chlorquinaldol and its related substances. Methods: Dikma-C_(18) column (250 mm×4. 6 mm, Hypersil, 5μm)with methanol-water-phosphoric acid(85: 15:0. 5) as mobile phase. The flow rate was 1 mL·min~(-1),the ultraviolet detection wavelength was 251 nm. Results:There was a good linar relationship within the range of 12-140μg·mL~(-1) (r=0.9999). The method was validated, and the stability tests under various conditions were performed. The reproducibility and precision of method were good(RSD=0. 33%). Conclusion; The method proposed for content determination of chlorquinaldol and its related substances by HPLC is simple, accurate, specific and could be used in quality control chlorquinaldol.