W. Rong
2009
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Journal
Chinese Journal of Pharmaceutical Analysis
Abstract
Objective:To establish HPLC method for the determination of prolonium iodide injection.Methods:The chromatographic conditions adopted were∶C18(150 mm×4.6 mm,5 μm)column,a mobile phase of 0.34%tetrabutylammonium hydrogen sulfate solution-acetonitrile(65∶35),and the flow rate at 1.0 mL·min-1;the detection wavelength at 225 nm;the column temperature was 35 ℃.Results:The calibrati on curves were linear in the range of 0.1-200 mg·L-1,the regression equation being Y=31218.5 X+44574.2(r=0.9997),and the average recovery(n=9) was 99.8%.Conclusion:The method is specific with good reproducibility and wide linear range.It can be applied to the quality control of prolonium iodide injection.