D. Chenoweth, B. W. Erickson, T. Hugli
Jan 30, 1979
Citations
0
Influential Citations
32
Citations
Quality indicators
Journal
Biochemical and biophysical research communications
Abstract
Abstract The pentapeptide L-methionyl-L-glutaminyl-L-leucyl-glycyl-L-arginine, which mimics the C-terminal sequence of human C5a anaphylatoxin, and two additional N-formylmethionyl derivatives of this peptide have been assessed for their ability to simulate C5a-related biological activities. Only the N-formylated peptides display chemotactic activity or induce lysosomal enzyme release when assayed with human neutrophils. Additional studies indicate that the active peptides, although designed after the C-terminal structure of the human C5a molecule, were apparently active because of their interaction with the N-formylmethionyl peptide receptor rather than the C5a receptor on neutrophils.