M. G. G. Cocco, M. D. C. STROZZI, PH.D D. CHu
Jun 1, 1979
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Clinical Cardiology
Abstract
The electrophysiological effect of dimeditiapramine (Ro 11‐1781), a Ca2+ antagonist, was evaluated in 20 patients with coronary heart disease. Electrophysiological measurements, including sinus cycle length, sinoatrial conduction time, intra‐atrial conduction time, atrial, atrioventricular, nodal and ventricular refractory periods and intraventricular conduction time were recorded before and after the intravenous administration of Ro 11‐1781. At a dose which is effective against cardiac arrhythmias, Ro 11‐1781 produced no statistically significant changes in the sinoatrial and intraventricular conduction time. Similarly, neither the sinoatrial nor the ventricular refractory period was affected. Ro 11‐1781, however, increased the atrioventricular conduction time and decreased the systolic blood pressure to a statistically significant extent. The tolerance was very good.