R. J. Harrison, SH Gowan, Lloyd R. Kelland
Sep 6, 1999
Citations
4
Influential Citations
151
Citations
Quality indicators
Journal
Bioorganic & medicinal chemistry letters
Abstract
A series of 3,6-disubstituted acridine derivatives have been rationally designed as telomerase inhibitors. They have been designed on the basis that inhibition of telomerase occurs by stabilising G-quadruplex structures formed by the folding of telomeric DNA. The most potent inhibitors have IC50 values against telomerase of between 1.3 and 8 microM, comparable to their cytotoxicity in ovarian cancer cell lines.