T. Rodgers, M. P. Lamontagne, A. Markovac
Apr 1, 1977
Citations
0
Influential Citations
52
Citations
Quality indicators
Journal
Journal of medicinal chemistry
Abstract
A series of 27 hydantoins was prepared and tested as antitumor agents. These were variously substituted in the 5 position but with special emphasis on the substituents (chloro, acetyl, chloroacetyl, and methyl) in the 1 and/or 3 positions. The most active compound was 5,5-bis(4-chlorophenyl)-1,3-dichlorohydantoin with a T/C value of 190% against P-388 lymphocytic leukemia in mice.