E. Malvoisin, M. Mercier, M. Roberfroid
1981
Citations
0
Influential Citations
24
Citations
Journal
Advances in experimental medicine and biology
Abstract
1,3-Butadiene is a major industrial chemical used in the production of synthetic elastomers such as polybutadiene and styrene-butadiene rubber (SBR). Like most of the unsaturated olefins, butadiene is metabolized in vivo. The first step of its biotransformation is the cytochrome P-450-dependent epoxidation to butadiene monoxide (Malvoisin et al, 1979). Both butadiene and butadiene monoxide have been shown to be mutagenic in the Ames test (de Meester et al, 1978).