C. Bianchini, P. Barbaro, G. Scapacci
Jun 26, 1998
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Quality indicators
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Organometallics
Abstract
The orthometalated dihydride complex fac-exo-(R)-[IrH2{C6H4C*H(Me)N(CH2CH2PPh2)2}] is an effective catalyst precursor for the enantioselective hydrogenation of 2-methylquinoxaline (MeQ) to 2-methyl-1,2,3,4-tetrahydroquinoxaline (MeTHQ) with ee's up to 90% (5 bar of H2, MeOH, 100 °C). In-situ high-pressure NMR spectroscopy in catalytic conditions shows that the catalytically active species is generated by deorthometalation rather than by H2 reductive elimination. 1H NMR spectroscopy also suggests that the two CN groups in MeQ are hydrogenated at comparable rates.