S. Doherty, J. Knight, Adam L. Bell
Mar 24, 2007
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0
Influential Citations
12
Citations
Journal
Organometallics
Abstract
Ruthenium(II) complexes of the type trans-[RuCl2{1,2-bis((diphenylphosphino)methyl)cyclohexane}(diamine)] based on the inexpensive and easy-to-prepare rac- and (S,S)-1,2-bis((diphenylphosphino)methyl)cyclohexane form highly active and enantioselective catalysts for the asymmetric hydrogenation of a wide range of aryl and heteroaryl ketones, in most cases giving ee's that exceed those obtained with their BINAP counterparts. Although precatalysts based on 1,2-bis((diphenylphosphino)methyl)cyclohexane slowly isomerize in solution to afford the thermodynamically favored isomer with a cis arrangement of chlorides, catalysts generated from both isomers afford similar enantioselectivities.