V. A. Gorpinchenko, D. V. Petrovcx, S. S. Lozhkin
Oct 1, 2009
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Journal
Chemistry of Heterocyclic Compounds
Abstract
Hydrogenation over Raney nickel of the methyl ester of 1H-pyrazoline-3-carboxylic acid and also of its 4-phenyl and 5-methoxycarbonyl-substituted analogs, leads respectively to 3-aminopyrrolidin-2-one, its 4-phenyl- and 5-methoxycarbonyl derivatives, predominantly to the trans isomer. Under the same conditions 1-amino-4-methoxycarbonylpyrrolidin-2-one was obtained from 3,4-di(methoxycarbonyl)-1H-pyrazoline, but 3,4,5-tri(methoxycarbonyl)-1H-pyrazoline did not react.