Mu-Wang Chen, Qing‐An Chen, Y. Duan
Jan 17, 2012
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0
Influential Citations
68
Citations
Journal
Chemical communications
Abstract
Asymmetric hydrogenolysis of racemic tertiary alcohols, 3-substituted 3-hydroxyisoindolin-1-ones, was developed using chiral phosphoric acid as catalyst and a Hantzsch ester as the hydrogen source with up to 95% ee. The reaction process of this asymmetric transfer hydrogenation may occur directly through the acyliminium ion intermediate.