H. Suemune, T. Harabe, Zhuofeng Xie
Nov 25, 1988
Citations
0
Influential Citations
25
Citations
Journal
Chemical & Pharmaceutical Bulletin
Abstract
Asymmetric hydrolysis of 2, 2-bis (acetoxymethyl) cyclopentanone (5) using biocatalysts and its application to a formal synthesis of (-)-malyngolide are described.For the asymmetric induction at the quaternary carbon of 5, cholinesterase from electric eel was found to be effective to afford the (+)-monoacetate (6)(90%ee).Compound (+)-6 was easily converted to the synthetic intermediate (28) for (-)-malyngolide.