N. Klempier, A. D. Raadt, H. Griengl
1992
Citations
0
Influential Citations
21
Citations
Journal
Journal of Heterocyclic Chemistry
Abstract
Chemoselective hydrolysis of heterocyclic nitriles can be achieved by an easy to use immobilized biocatalyst prepared from Rhodococcus sp. Pyrimidine-2-carbonitrile (2a) and 3-chloropyridazine-4-carbonitrile (4a) were converted into the corresponding amides while from 2-ethoxycarbonyl-4-pyridinecarbonitrile (1a), 6-methylpyridazine-3-carbonitrile (3a), 3-chloropyridazine-4-carbonitrile (4a), 3-ethoxycarbonyl-4,5-dihydroisoxazole-5-carbonitrile (8a), indole-3-carbonitrile (9a) and indole-3-ylacetonitrile (10a) the acids were formed.