H. Bundgaard, U. Klixbüll
Dec 1, 1985
Citations
0
Influential Citations
12
Citations
Quality indicators
Journal
International Journal of Pharmaceutics
Abstract
Abstract The degradation of pivampicillin, an ampicillin prodrug, was studied in phosphate buffer solutions of pH 7.40 and in human plasma solutions. The degradation course of pivampicillin was found to involve a quantitative hydrolysis of the pivaloyl ester moiety followed by a reversible reaction between the initial hydrolysis products, ampicillin and formaldehyde, to yield a 4-imidazolidinone derivative of ampicillin. This secondary reaction was shown to account for previously reported findings of decreased yields of both ampicillin and formaldehyde upon the enzymatic and non-enzymatic degradation of pivampicillin.